Glomelleran

The glucan exhibited a strong inhibition of tumor growth of the allogeneic Sarcoma-180 as well as the syngeneic DBA/2-MC.SC-1 fibrosarcoma with inhibition ratios up to 100% [1].

Against the hormone sensitive Noble-Nb-R prostate carcinoma the glucan alone showed a moderate antitumor effect, whereas in combination with diethylstilbestrol an almost complete regression of the tumor could be achieved [1].

It could be demonstrated that a highly ordered structure of the glucan is not essential for the antitumor activity. Since the glucan expressed no direct cytotoxic effects, the immunomodulating activity was investigated in vitro in order to get an indication for a possible mode of action [1].

Moreover, the glucan stimulated the phagocytosis of zymosan by bone marrow macrophages up to 100%. However, the glucan was not able to render macrophages cytotoxic against P-815 mastocytoma cells [1].