Arabinogalactan

Biological properties


Ukonan C is phagocytosis-activating, anti-complementary and alkaline phosphatase-inducing [2].

Arabinogalactan II is found joined to hydroxyproline rich proteins, indicating, that it can form a point of union between polysaccharides of the cell and proteins [8].

Intravenous arabinogalactan from Larix occidentalis ends in the liver. It has therefore been tested as a hepatic drug delivery agent [9].


Molecular biology


Attached to a peptidoglycan thru a phosphodiester link in mycobacteria, involving the special linker (→4)-Rhap-(1→3)-GlcNAc-(1→P→6)-MurUA-(6→) [4]. The arabinogalactan from Mycobacterium tuberculosis show antigenic activity. This is from the arabinysyl residues, largely from fractions containing 2-linked arabinosylresidues [6].

10-35% inhibition on the restriction enzyme HindIII at 100 μg polysaccharide / μg λ DNA, and 75-95% inhibition at 500 μg polysaccharide / μg λ DNA [10].